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Acne is a complex skin disorder involving increased sebum secretion, abnormal keratinization, bacterial overgrowth, and inflammation. Testosterone and dihydrotestosterone (DHT) act as key factors by binding to androgen receptors, activating genes responsible for sebocyte proliferation, sebum overproduction, and inflammatory cytokine release. Clascoterone competes with these hormones, blocking receptor activation and preventing acne progression.
Additionally, androgenetic alopecia is a genetic, hormone-driven condition where DHT binds to androgen receptors in scalp dermal papilla cells, triggering hair loss. By preventing DHT interaction, Clascoterone inhibits this process, reducing hair thinning.
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✅ Description:
Acnev cream is an androgen receptor blocker used for treating acne vulgaris in individuals aged 12 years and above.
Clascoterone (cortexolone 17 α-propionate) is a novel androgen receptor antagonist. It binds with high affinity, inhibiting androgen receptor signaling pathways that contribute to acne development, such as sebaceous gland growth, excessive sebum production, and inflammation.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage & Administration of Acnev 1% Cream
- Clean affected areas before applying a thin layer (approximately 1g) of Acnev cream twice daily (morning and evening).
- Avoid contact with eyes, mouth, or mucous membranes; rinse thoroughly with water if exposure occurs.
- Not recommended for children under 12 years due to lack of safety data.
✔️ Common adverse effects (7-12% incidence) include:
- Skin reactions: Redness (erythema), itching (pruritus), and dryness (scaling).
- Less frequent (>3% incidence): Swelling (edema), burning, and stinging sensations.
In clinical trials with 1,421 participants (aged 12+), side effects occurred at similar rates in both the treatment and placebo groups.
✔️ Drug Interactions
No clinical studies have been conducted on potential drug interactions with Acnev cream.
✔️ Contraindications
No specific contraindication data is available for Clascoterone cream.
✔️ Pregnancy & Lactation
- No sufficient data to assess risks for birth defects, miscarriage, or maternal/fetal complications.
- Unknown if Clascoterone is excreted in breast milk or affects lactation.
✔️ Precautions & Warnings
- Skin irritation: May cause redness, itching, burning, or peeling. Discontinue or reduce use if symptoms worsen.
- HPA axis suppression: Potential adrenal gland suppression, especially in pediatric patients.
- Hyperkalemia risk: Some cases of elevated potassium levels were observed during clinical trials.
✔️ Storage Instructions
- Store at 2°-8°C before dispensing.
- After opening, keep at 20°-25°C for up to 90 days.
- Protect from light and moisture.
- Keep out of reach of children.
